博士 教授
E-mail: yangchuanzhen@bnu.edu.cn
个人主页：暂无
教育经历：
(1) 2009-09 至 2013-07, 中央民族大学, 生命与环境科学学院，理学学士
(2) 2013-09 至 2018-07, 北京大学, 生命科学学院，理学博士
工作经历：
(1) 2018-08 至 2023-06, 首都医科大学, 基础医学院, 讲师
(2) 2023-07 至 2026-03, 西湖实验室（生命科学和生物医学浙江省实验室）, 副研究员
(3) 2026-03 至今, 北京师范大学, 生命科学学院，教授
长期从事细胞代谢与肿瘤等疾病的发生发展关系研究。近年来以第一作者或通讯作者（含共同）发表论文多篇，包括Nature Cell Biology（2023）、 Nature Communications（2022，2024）、Journal of Experimental Medicine（2020）、Journal of Biological Chemistry（2019）、Cancer Research（2018）、Cell Death Discovery（2021）和Cancer Biology & Medicine（2019）等。多次受邀为Nature Communications, Protein & Cell, Communications Biology等领域内主流期刊多次审稿。主持承担国家自然科学青年科学基金项目B类（原优秀青年科学基金项目）、C类、面上项目、北京市自然科学青年科学基金项目以及浙江省自然科学基金重点项目，并入选第九届中国科协青年人才托举工程。获2024年北京市科学技术奖自然科学奖二等奖、2023年首都医科大学科学技术奖自然科学奖一等奖以及授权发明专利1项。
1.解析肿瘤代谢重编程的分子机制并寻找针对代谢脆性的分子靶点；
2.探索代谢-免疫互作网络在肿瘤微环境中的动态调控并开发干预策略；
3.解析代谢脂肪性肝病进程中关键代谢节点并阐明其对疾病恶性转化的调控机制；
4.研究代谢调控特定细胞死亡方式的分子机制。
课题组长期欢迎对肿瘤代谢研究感兴趣的博士后、研究生和本科生加入。
研究性论文：（†共同第一作者；*通讯作者）
1. Chuanzhen Yang#, Yiliang Zhao#, Liao Wang#, Zihao Guo, Lingdi Ma, Ronghui Yang, Ying Wu, Xuexue Li, Jing Niu, Qiaoyun Chu, Yanxia Fu and Binghui Li*. De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defense. Nat Cell Biol, 2023, 25(6):836-847.
2. Zihao Guo, Yang Zhang, Haoyue Wang, Liming Liao, Lingdi Ma, Yiliang Zhao, Ronghui Yang, Xuexue Li, Jing Niu, Qiaoyun Chu, Yanxia Fu, Binghui Li*, Chuanzhen Yang*. Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle. Nat Commun, 2024, 15(1): 6915.
3. Ronghui Yang#, Chuanzhen Yang#, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li*. Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress. Nat Commun, 2022, 13(1): 7031.
4. Miao Liu#, Yuanyuan Wang#, Chuanzhen Yang#, Yuxia Ruan#, Changsen Bai, Qiaoyun Chu, Yanfen Cui, Ceshi Chen, Guoguang Ying, Binghui Li*. Inhibiting both proline biosynthesis and lipogenesis synergistically suppress tumor growth. J Exp Med, 2020, 217(3).
5. Chuanzhen Yang, Weicheng Zang, Zefang Tang, Yapeng Ji, Ruidan Xu, Aiping Luo, Bin Hu, Zemin Zhang, Zhihua Liu, Xiaofeng Zheng*. A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy. Cancer Res, 2018, 78(4): 1069-1082.
6. Chuanzhen Yang#, Weicheng Zang#, Yapeng Ji, Tingting Li，Yongfeng Yang，Xiaofeng Zheng*. Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly (ADP-ribose) polymerase-dependent manner and regulates the DNA damage response. J Biol Chem, 2019, 294(8): 2827-2838.
7. Ronghui Yang, Zihao Guo, Yiliang Zhao, Lingdi Ma, Binghui Li, Chuanzhen Yang*. Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase. Cell Death Discov, 2021, 7(1):204.
8. Liao Wang#, Yinghui Sun#, Xijie Liu, Hongjuan Li, Chang Lu, Ronghui Yang, Chuanzhen Yang*, Binghui Li*. SY-1530, a highly selective BTK inhibitor, effectively treats B-cell malignancies by blocking B-cell activation. Cancer Biol Med, 2021, 19(7):995-1007.
9. Yapeng Ji, Chuanzhen Yang, Zefang Tang, Yongfeng Yang, Yonglu Tian, Hongwei Yao, Xi Zhu, Zemin Zhang, Jiafu Ji, Xiaofeng Zheng*. Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Nat Commun, 2017, 8: 15308.
10. Weicheng Zang, Chuanzhen Yang, Tingting Li, Liming Liao, Xiaofeng Zheng*. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Proc Natl Acad Sci U S A, 2019, 116(51): 25624-25633.
11. Yongfeng Yang, Chuanzhen Yang, Tingting Li, Shuyu Yu, Tingting Gan, Jiazhi Hu, Jun Cui and Xiaofeng Zheng*. The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults. Cancer Res, 2020,80(4):719-731.
12. Fengxiang Wang#, Cuiji Sun#, Tianshu William Wu #, Yuting Fu, Yujing Fan, Shuchang Zhao, Kaiyin Huang, Zijian Pan, Yang Lu, Jingrong Regina Han, Shikai Jia, Lizhou Zeng, Sheng Zhang, Ting Chen, Shaowei An, Shuang Susie Meng, Xun Guo, Weizhe Li, Heyuan Lian, Xiaoting Sun, Jin Hu, Chuanzhen Yang, Shan Feng, Pengfei Li, Liyuan Du, Xiaodong Liu, Kiryl D Piatkevich*, Yilong Zou*. iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion. Nature, 2026, 649(8096):505-514.
13. Yuanyuan Wang#, Changsen Bai#, Yuxia Ruan#, Miao Liu, Qiaoyun Chu, Li Qiu, Chuanzhen Yang, Binghui Li*. Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia. Nat Commun, 2019, 10(1): 201.
14. Qiaoyun Chu#, Jing An#, Ping Liu, Yihan Song, Xuewei Zhai, Ronghui Yang, Jing Niu, Chuanzhen Yang, Binghui Li*. Repurposing a tricyclic antidepressant in tumor and metabolism disease treatment through fatty acid uptake inhibition. J Exp Med, 2023, 220(3): e20221316.
15. Qiaoyun Chu#, Ping Liu#, Yihan Song#, Ronghui Yang#, Jing An, Xuewei Zhai, Jing Niu, Chuanzhen Yang, Binghui Li*. Stearate-derived very long-chain fatty acids are indispensable to tumor growth. EMBO J, 2023. 42(2): e111268.